Milan revamp with Luka Jovic, Noah Okafor and Christian Pulisic, while Torino have Duvan Zapata and Pietro Pellegri in a push for Europe.
It kicks off at the Stadio Olimpico Grande Torino at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from this game and Lecce-Atalanta on the LIVEBLOG.
Stefano Pioli is already guaranteed second place, so is taking the opportunity to reshuffle his squad and for the second game in a row leaves Rafael Leao and Olivier Giroud on the bench.
Mike Maignan, Simon Kjaer, Ruben Loftus-Cheek and Samuel Chukwueze are injured, with Matteo Gabbia suspended, while Theo Hernandez is struggling with flu symptoms, so Filippo Terracciano starts.
Torino still have some slender hope of securing Conference League qualification after Fiorentina and Napoli drew 2-2 last night.
Nikola Vlasic, Koffi Djidji, Gvidas Gineitis and Perr Schuurs are out of action, but Alessandro Buongiorno and Duvan Zapata pass fitness tests to start.
Torino vs. Milan line-ups
Torino: Milinkovic-Savic; Tameze, Buongiorno, Masina; Bellanova, Ilic, Linetty, Rodriguez; Ricci; Pellegri, Zapata
Milan: Sportiello; Kalulu, Tomori, Thiaw, Terracciano; Musah, Reijnders, Bennacer; Pulisic, Jovic, Okafor
32
5
4
80′ 19
74′ 13
61′ 61
8
77
28
91
11
74′ 57
23
28
20
38
65′ 4
78′ 14
80
77′ 11
15
17
61′ 26
1
21
81
15
71
25
17
79
30
27
61′ 9
74′ 20
74′ 6
80′ 16
83
2
30
7
85
95
10
61′ 42
65′ 9
77′ 32
78′
Source link: Torino vs. Milan official Serie A Week 37 line-ups